Attenuation of hemodynamic pressor response to laryngoscopy and endotracheal intubation by intravenous fentanyl in elective surgery under general anesthesia: A randomized controlled trial using three different doses

Background: Direct laryngoscopy and endotracheal intubation elicit hemodynamic pressor responses which may be hazardous in high risk patients. Fentanyl, a low cost synthetic opioid, when used judiciously, good option to attenuate this stress response. Aims Objectives: The present study has been conducted compare the efficacy of three different doses intravenous fentanyl attenuation response elective surgery under general anesthesia. Materials Methods: It was double-blinded randomized controlled trial. A total 90 patients American Society Anesthesiologists physical status I II, 55 male 35 female, aged between 20 years, were into groups receiving 2, 3, 4 μg/kg injection fentanyl, respectively, administered intravenously 5 min before direct intubation. Results: There significant differences variables among all at 1, 5, 10 after Just intubation; heart rate, mean arterial pressure, diastolic pressure – these showed significance 3 only. Incidence nausea/vomiting statistical 2 Conclusion: In our trial, intubation, superior suppressing associated with it. Further, larger trials are needed confirm findings.